Fig. 9.

Crosstalk between cancer and immune cells.

(a) Overview of selected ligand-receptor interactions of tumor cells and immune cells. The line thickness is proportional to the number of ligands when cognate receptors are present in the recipient cell type. The loops indicate autocrine circuits.

(b) Detailed view of the ligands expressed by each cell type and the other cell types. Numbers indicate the quantity of ligand-receptor pairs for each intercellular link.

(c–e) Bubble plot showing the selected ligand-receptor interactions between cancer cells and T cell (c), myeloid cells (d), and B cells (e). P values are indicated by circle size, with the scale to the right (permutation test).