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. Author manuscript; available in PMC: 2022 Jan 6.
Published in final edited form as: Neuroendocrinology. 2021 Jan 6;111(12):1151–1163. doi: 10.1159/000514217

Fig. 2:

Fig. 2:

The central administration of IGF-1 advanced the timing of puberty. Open and solid bars represent the mean (±SEM) age in days at vaginal opening for saline and IGF-1-treated animals, respectively. Note that IGF-1 advanced vaginal opening by 4.9 days. N = 6–7/bar. *** p<0.001. (With permission, © 1996 by The Endocrine Society, [13] Hiney JK, Srivastava V, Nyberg CL, Ojeda SR, Dees WL; Endocrinology published by Oxford University Press.)