Table 1.
Clinical characteristics for n = 282 infants, born 01/01/2007–31/12/2017.
| Baseline characteristics 2007 to 2017 (n = 282) | |
| Outborn, number (%) | 159/282 (56.4) |
| Male, number (%) | 159/282 (56.4) |
| Gestational age in weeks, median (IQR) | 40.0 (38.3, 41.0) |
| CPR at birth, number (%) | 103/282 (36.5) |
| Duration (min) of CPR, median (IQR) | 0.0 (0.0, 2.3) |
| Needing ventilation (intubated or bagged) at 10 min, number (%) | 222/282 (78.7) |
| Birth weight in grams, median (IQR) | 3361 (2983, 3780) |
| Apgar 10 min, median (IQR) | 6 (4, 8) |
| Apgar 10 min ≤5, number (%) | 105/282 (37.2) |
| Worst pH within 1 h of birth, median (IQR) | 6.96 (6.85, 7.09) |
| Worst pH within 1 hour of birth <7.0, number (%) | 156/282 (55.3) |
| Worst base excess within 1 h of birth, median (IQR) | −16.0 (−12.6, −20.5) |
| Worst base excess within 1 h of birth ≤−16 mmol/L, number (%) | 138/282 (48.9) |
| Normal aEEG voltage*, number (%) | 9/282 (3.2) |
| Moderately abnormal aEEG voltage*, number (%) | 219/282 (77.7) |
| Severely abnormal aEEG voltage*, number (%) | 54/282 (19.1) |
| HIE grade 2, number (%) | 186/282 (66.0) |
| HIE grade 3, number (%) | 96/282 (34.0) |
| Death, number (%) | 24/282 (8.5) |
| Mechanical ventilation and SA during 1st week of life in survivors (n = 258) | |
| Intubation duration in hours, median (IQR) | 96 (86, 112) |
| Duration (h) end of active cooling to extubation, median (IQR) | 23 (14, 35) |
| Duration (h) end of SA delivery to extubation, median (IQR) | 7 (2, 16) |
| Sedation duration, median (IQR) | 86 (79, 97) |
| Cumulative morphine µg/kg, median (IQR) | 2052 (1291, 2628) |
| Additional fentanyl or remifentanil, number (%) | 28/258 (10.9) |
| Bolus, number (%) | 14/28 (50.0) |
| Continuous infusion, number (%) | 14/28 (50.0) |
| Cumulative non-converted fentanyl (µg/kg) median (IQR) | 7.5 (3.0, 126.1) |
| Cumulative converted SA µg/kg, median (IQR) | 2121 (1343, 2741) |
*Voltage classification of aEEG for entry-criteria (pattern classification groups). Normal aEEG voltage: Continuous Normal Voltage (CNV). Moderately abnormal aEEG voltage: continuous normal voltage with seizures (CNVsz) or Discontinuous Normal Voltage (DNV), or Burst Suppression (BS).
Severely abnormal aEEG voltage: Low Voltage (LV) or Flat Trace (FT).