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. 2021 Jul 3;8(4):ENEURO.0066-21.2021. doi: 10.1523/ENEURO.0066-21.2021

Figure 5.

Figure 5.

iPSC-derived cortical NPCs and organoids from autistic individuals show altered expression of CDH8 and CDH11. Western blot analysis and quantification of (A) CDH8 and (B) CDH11 expression in iPSC-derived cortical NPCs from typically-developing control and autistic individuals at 19 DIV. Quantification of the expression of each cadherin is represented as bar graph and as box and whisker plot; *p < 0.05, **p < 0.01; unpaired two-tailed t test. N = 4 control and 8 autistic individuals, triplicates of each individual. Cadherin signals were normalized to GAPDH. Quantification of mRNA expression of (C) CDH8 and (D) CDH11 in cortical organoids derived from iPSCs of control and autistic individuals at 60 DIV via qPCR; *p < 0.05, ***p < 0.001; unpaired two-tailed t test. N = 4 control and 6 autism individuals, triplicates of each individual.