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. 2021 Jul 1;148(13):dev199561. doi: 10.1242/dev.199561

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Dynamics of differentially expressed proteins during cytotrophoblast differentiation/invasion. (A) Unsupervised fuzzy clustering of 477 differentially expressed (DE) proteins identified four clusters with distinct expression profiles. n=number of proteins assigned to each cluster. (B) Heatmap of gene ontology (GO) enrichment analysis of each cluster. GO terms overrepresented in each cluster (Fisher's exact test; P<0.05, unadjusted) were visualized by fold enrichment as a qualitative comparison to functionalities in other clusters. (C) Representative GO terms enriched in clusters 1 and 2 (Fisher's exact test; P<0.05, Benjamini-Hochberg corrected) were visualized for biological processes, cellular component or molecular function (MF).