REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal anti-FGF2	Signalway Antibody	#36769
Rabbit polyclonal anti-ATF6	Signalway Antibody	#32008
Rabbit monoclonal anti-ATF6	Abcam	#ab227830
Rabbit monoclonal anti-GRP78	Cell Signaling Technology	AB_2119845
Rabbit monoclonal anti-GRP94	Cell Signaling Technology	AB_2722657
Rabbit monoclonal anti-GAPDH	Cell Signaling Technology	AB_10622025
Rabbit polyclonal anti-CD31	Abcam	AB_726362
Rabbit polyclonal anti-OSX	Abcam	AB_10675660
Goat polyclonal anti-FGF2	R&D systems	AB_2104324
Biological samples
Patient-derived articular cartilage	Sun Yat-sen Memorial Hospital (Sun Yat-sen University, Guangzhou, China)	N/A
Chemicals, peptides, and recombinant proteins
Curdlan	InvivoGen	tlrl-curd
Thapsigargin	Sigma-Aldrich	67526-95-8
Tunicamycin	Sigma-Aldrich	11089-65-9
4-phenyl butyric acid	Sigma-Aldrich	15118-60-2
Ceapin-A7	Sigma-Aldrich	2323027-38-7
Recombinant human TNF-α	PeproTech	300-01A
Recombinant human IFN-γ	PeproTech	300-02
Recombinant human IL-17	PeproTech	200-17
Critical commercial assays
Human FGF basic DuoSet ELISA	R&D systems	DY233
SimpleChIP Enzymatic ChIP Kit	Cell Signaling Technology	#9002
Experimental models: cell lines
human umbilical vein endothelial cells	iCell Bioscience	iCell-0045a
human embryonic kidney cell line 293T	iCell Bioscience	iCell-h237
Experimental models: organisms/strains
Mouse: C57BL/6N	The Guangdong Medical Laboratory Animal Center	N/A
Mouse: BALB/c	The Guangdong Medical Laboratory Animal Center	N/A
Mouse: SKG	S. Sakaguchi (University of Kyoto, Kyoto, Japan)	N/A
Mouse: C57BL/6J	the National Laboratory Animal Center (Taipei, Taiwan)	RMRC11005
Oligonucleotides
Primers used in qRT-PCR for VEGF, FGF2, IGF-1, EGF, TGF-β, IL-6, GAPDH, GRP78, GRP94, IRE1, PERK, and ATF6, see Table S2	This paper	N/A
Primer used in CHIP: GRP78 Forward: 5’-GCG GAG CAG TGA CGT TTA TT-3’ Reverse: 5’-GAC CTC ACC GTC GCC TAC T-3’	This paper	N/A
Primer used in CHIP: FGF2 M1 Forward: 5’-TCTGAGCAAATAGGCCTTGCT-3’ Reverse: 5’-GGCTGAAGCCCCTGTAACAAA-3’	This paper	N/A
Primer used in CHIP: FGF2 M2 Forward: 5’-ATATGCCTGGTTTTGGGCCT-3’ Reverse: 5’-CAGCCTACCGAATAGCTGGG-3’	This paper	N/A
Plasmid: Pcgn-ATF6	Addgene	#11974
Plasmid: Pcgn-ATF6 (1-373)	Addgene	#27173
Plasmid: Pcgn-ATF6 (1-373) m1	Addgene	#27174
Software and algorithms
ImageJ software	National Institutes of Health	imagej.nih.gov/ij/
MicroCT Ray software V3.0	Scanco Medical	http://www.scanco.ch/
Other
angiogenesis μ-slides	Ibidi	81506