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. 2021 Jul 16;64(9):1560–1563. doi: 10.1007/s11427-021-1972-1

On the origin of SARS-CoV-2—The blind watchmaker argument

Chung-I Wu 1,✉, Haijun Wen 1, Jian Lu 2, Xiao-dong Su 2, Alice C Hughes 3, Weiwei Zhai 4, Chen Chen 5, Hua Chen 6, Mingkun Li 6, Shuhui Song 6, Zhaohui Qian 7, Qihui Wang 8, Bingjie Chen 1, Zixiao Guo 1, Yongsen Ruan 1, Xuemei Lu 9, Fuwen Wei 10, Li Jin 11, Le Kang 12, Yongbiao Xue 6, Guoping Zhao 13, Ya-Ping Zhang 9
PMCID: PMC8284035  PMID: 34269976

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Compliance and ethics The author(s) declare that they have no conflict of interest.

References

  1. Althoff KN, Schlueter DJ, Anton-Culver H, Cherry J, Denny JC, Thomsen I, Karlson EW, Havers FP, Cicek MS, Thibodeau SN, et al. Clin Infect Dis. 2021. Antibodies to SARS-CoV-2 in All of Us Research Program Participants, January 2–March 18, 2020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bajic G, Maron MJ, Adachi Y, Onodera T, McCarthy KR, McGee CE, Sempowski GD, Takahashi Y, Kelsoe G, Kuraoka M, Schmidt AG. Influenza antigen engineering focuses immune responses to a subdominant but broadly protective viral epitope. Cell Host Microbe. 2019;25:827–835.e6. doi: 10.1016/j.chom.2019.04.003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, et al. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proc Natl Acad Sci USA. 2008;105:19944–19949. doi: 10.1073/pnas.0808116105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bloom JD, Chan YA, Baric RS, Bjorkman PJ, Cobey S, Deverman BE, Fisman DN, Gupta R, Iwasaki A, Lipsitch M, et al. Investigate the origins of COVID-19. Science. 2021;372:694.1–694. doi: 10.1126/science.abj0016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Crosby AW. America’s Forgotten Pandemic: The Influenza of 1918. 2003. [Google Scholar]
  6. Davies NG, Abbott S, Barnard RC, Jarvis CI, Kucharski AJ, Munday JD, Pearson CAB, Russell TW, Tully DC, Washburne AD, et al. Estimated transmissibility and impact of SARSCoV-2 lineage B.1.1.7 in England. Science. 2021;372:eabg3055. doi: 10.1126/science.abg3055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dawkins R. The Blind Watchmaker: Why the Evidence of Evolution Reveals a Universe without Design. 1996. [Google Scholar]
  8. Dinnon KH, III, Leist SR, Schäfer A, Edwards CE, Martinez DR, Montgomery SA, West A, Yount BL, Jr, Hou YJ, Adams LE, et al. A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. Nature. 2020;586:560–566. doi: 10.1038/s41586-020-2708-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Goldschmidt, R. (1982). The Material Basis of Evolution, Vol 28 (Yale University Press).
  10. Gu H, Chen Q, Yang G, He L, Fan H, Deng YQ, Wang Y, Teng Y, Zhao Z, Cui Y, et al. Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy. Science. 2020;369:1603–1607. doi: 10.1126/science.abc4730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gu J, Yan H, Huang Y, Zhu Y, Sun H, Qiu Y, Chen S. Comparing containment measures among nations by epidemiological effects of COVID-19. Natl Sci Rev. 2020;7:1847–1851. doi: 10.1093/nsr/nwaa243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hu J, Lei C, Chen Z, Liu W, Hu X, Pei R, Su Z, Deng F, Huang Y, Sun X, et al. Distribution of airborne SARS-CoV-2 and possible aerosol transmission in Wuhan hospitals. China. Natl Sci Rev. 2020;7:1865–1867. doi: 10.1093/nsr/nwaa250. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Huynh J, Li S, Yount B, Smith A, Sturges L, Olsen JC, Nagel J, Johnson JB, Agnihothram S, Gates JE, et al. Evidence supporting a zoonotic origin of human coronavirus strain NL63. J Virol. 2012;86:12816–12825. doi: 10.1128/JVI.00906-12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B, et al. Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell. 2020;182:812–827.e19. doi: 10.1016/j.cell.2020.06.043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. La Rosa G, Mancini P, Bonanno Ferraro G, Veneri C, Iaconelli M, Bonadonna L, Lucentini L, Suffredini E. SARS-CoV-2 has been circulating in northern Italy since December 2019: Evidence from environmental monitoring. Sci Total Environ. 2021;750:141711. doi: 10.1016/j.scitotenv.2020.141711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Leist SR, Dinnon KH, III, Schäfer A, Tse LV, Okuda K, Hou YJ, West A, Edwards CE, Sanders W, Fritch EJ, et al. A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice. Cell. 2020;183:1070–1085.e12. doi: 10.1016/j.cell.2020.09.050. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Menachery VD, Yount BL, Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, et al. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015;21:1508–1513. doi: 10.1038/nm.3985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Normile D. Understanding the enemy. Science. 2013;339:1269–1273. doi: 10.1126/science.339.6125.1269. [DOI] [PubMed] [Google Scholar]
  19. Paley W. Natural Theology: or, Evidences of the Existence and Attributes of the Deity, Collected from the Appearances of Nature. 1829. [Google Scholar]
  20. Randazzo W, Truchado P, Cuevas-Ferrando E, Simón P, Allende A, Sánchez G. SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area. Water Res. 2020;181:115942. doi: 10.1016/j.watres.2020.115942. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Ruan Y, Luo Z, Tang X, Li G, Wen H, He X, Lu X, Lu J, Wu CI. On the founder effect in COVID-19 outbreaks: how many infected travelers may have started them all? Natl Sci Rev. 2021;8:nwaa246. doi: 10.1093/nsr/nwaa246. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Ruan Y, Wen H, He X, Wu CI. A theoretical exploration of the origin and early evolution of a pandemic. Sci Bull. 2021;66:1022–1029. doi: 10.1016/j.scib.2020.12.020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sallard E, Halloy J, Casane D, Decroly E, van Helden J. Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review. Environ Chem Lett. 2021;19:769–785. doi: 10.1007/s10311-020-01151-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Segreto R, Deigin Y. The genetic structure of SARS-CoV-2 does not rule out a laboratory origin. BioEssays. 2021;43:2000240. doi: 10.1002/bies.202000240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Sharp PM, Hahn BH. Origins of HIV and the AIDS pandemic. Cold Spring Harb Perspect Med. 2011;1:a006841. doi: 10.1101/cshperspect.a006841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Tang X, Wu C, Li X, Song Y, Yao X, Wu X, Duan Y, Zhang H, Wang Y, Qian Z. On the origin and continuing evolution of SARS-CoV-2. Natl Sci Rev. 2020;7:1012–1023. doi: 10.1093/nsr/nwaa036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, Doolabh D, Pillay S, San EJ, Msomi N. medRxiv. 2020. Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa. [Google Scholar]
  28. Voloch, C.M., da Silva Francisco, R., de Almeida, L.G.P., Cardoso, C.C., Brustolini, O.J., Gerber, A.L., Guimarães, A.P.C., Mariani, D., da Costa, R.M., Ferreira, O.C., Frauches, T.S., de Mello, C.M.B., Leitão, I.C., Galliez, R.M., Faffe, D.S., Castiñeiras, T.M.P.P., Tanuri, A., and de Vasconcelos, A.T.R. (2021). Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil. J Virol 95. [DOI] [PMC free article] [PubMed]
  29. Zhou H, Ji J, Chen X, Bi Y, Li J, Wang Q, Hu T, Song H, Zhao R, Chen Y, Cui M, Zhang Y, Hughes AC, Holmes EC, Shi W. Cell. 2021. Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses. [DOI] [PMC free article] [PubMed] [Google Scholar]

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