NEUROSCIENCE Correction for “Subregion-specific rules govern the distribution of neuronal immediate-early gene induction,” by Ben Jerry Gonzales, Diptendu Mukherjee, Reut Ashwal-Fluss, Yonatan Loewenstein, and Ami Citri, which was first published October 21, 2019; 10.1073/pnas.1913658116 (Proc. Natl. Acad. Sci. U.S.A. 117, 23304–23310).
The authors note that: “The R analysis for panel B in Fig. 3 was accidently run on the wrong file. This panel has now been corrected based on the correct file. This mistake erroneously represented subtle changes in the control and cocaine conditions, but did not impact any of the statements in the manuscript. The slope value in Fig. 3 panel C (Egr2-D2 correlation scatter plot following cocaine) was erroneously rounded to 0.2 instead of 0.19. This is now corrected in the revised Fig. 3. Due to typos in panel C and D of Fig. S5, r2 values appeared with a negative (−) sign. This has been corrected in the revised SI Appendix. These errors do not change the conclusions of the article.” The corrected Fig. 3 and its legend appear below. The SI Appendix has been corrected online.
Fig. 3.
Differential recruitment of Drd1 and Drd2 SPNs in ventrolateral vs. medial striatum. (A) Cartoon depiction of the location of ventrolateral (VLS) and medial (MS) striatal regions and representative high-magnification 40× images showing Egr2 expression within Drd1- or Drd2-expressing SPNs in VLS (Left) and MS (Right) in control vs. cocaine. (B and C) Scatter plots of Egr2 expression as a function of Drd1 or Drd2 expression within single cells in the VLS (B) and MS (C); n = 6 sections from 3 mice in each condition; VLS, 18,165 to 18,622 cells; MS, 31,008 to 31,920 cells. P < 0.0001. (D and E) Cocaine-induced Egr2 expression correlates with Drd1 expression in the VLS (D), and Drd1, as well as Drd2 expression in the MS (E). Each dot represents the mean gene expression for each replicate bin, while the line represents the mean. n = 6 sections from 3 mice for each condition; VLS, 18,165 to 18,622 cells; MS, 31,008 to 31,920 cells (P < 0.005 for all conditions except VLS Drd2, which was nonsignificant; ANOVA).