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. 2021 Jun 9;10:182. Originally published 2021 Mar 5. [Version 2] doi: 10.12688/f1000research.28510.2

Figure 6. VtRNA promoters DNA methylation in Normal vs. Tumor samples.

Figure 6.

Average beta-values of promoter DNA methylation for vtRNA1-1 ( A) vtRNA1-2 ( B), vtRNA1-3 ( C) and vtRNA2-1 ( D). Acronyms indicate the tissue condition (normal (N) and tumor (T)). Blue and red colors indicate an increase or reduction in promoter methylation in tumor vs their normal tissues counterparts. The box plots show the median and the lower and upper quartile, and the whiskers the 2.5 and 97.5 percentile of the distribution. Horizontal, lines denote the methylation level of the promoters: grey striped bottom and top for unmethylated (average beta-value ≤ 0.2) or highly methylated (average beta-value ≥ 0.8) respectively, and red dotted for 50% methylated (average beta-value = 0.5)) promoters. One-way ANOVA multiple test analysis with Sidak as posthoc test was performed. * p-value < 0.05; ** p-value < 0.01; **** p-value < 0.0001.