Table 3.

Performance of SACOV-19 and single variables removing patients with missing values

	Balanced accuracy	Sensitivity	Specificity	Odds ratio	95% CI
					Lower	Upper
Performance of the score at different thresholds for the validation set
SACOV-19 ≥ 5	0.66	0.58	0.74	4.04	1.97	8.32
SACOV-19 ≥ 4	0.73	0.83	0.62	8.13	3.45	19.11
SACOV-19 ≥ 3	0.65	0.92	0.38	6.77	2.26	20.27
Performance of single binary variables
Oxygen saturation < 96%a	0.63	0.53	0.73	3.07	2.34	4.04
Age > 65 years	0.62	0.60	0.65	2.75	2.16	3.51
CRP > 29 mg/L	0.62	0.53	0.70	2.67	2.04	3.49
LDH > ULN	0.61	0.65	0.57	2.40	1.80	3.21
Temperature > 37.3 °C	0.60	0.68	0.53	2.37	1.83	3.08
Urine total protein positive	0.60	0.57	0.63	2.27	1.44	3.60
Hypertension	0.59	0.54	0.64	2.13	1.68	2.72
IL6 > 199 ng/L	0.59	0.29	0.90	3.48	1.88	6.45
Lymphocyte counts < 800/µL	0.59	0.47	0.71	2.17	1.59	2.94
D-dimer > ULN	0.59	0.70	0.47	2.08	1.41	3.08
Creatinine > ULN b	0.58	0.34	0.81	2.22	1.64	2.99
BMI > 24.9 kg/${\mathrm{m}}^2$	0.57	0.64	0.51	1.84	1.34	2.53
Urea > ULN	0.57	0.29	0.86	2.40	1.70	3.40
Ferritin > 299 ng/mL	0.57	0.65	0.49	1.77	1.15	2.72
Urine ketone bodies positive	0.57	0.32	0.82	2.10	1.26	3.49
PaO2 < 80 mmHg	0.57	0.46	0.67	1.76	0.92	3.35
AST > ULN	0.56	0.35	0.78	1.89	1.37	2.59
Respiratory rate > 21 per min	0.56	0.29	0.84	2.09	1.43	3.05
Use of ACE/AT1	0.56	0.40	0.72	1.74	1.36	2.25
Hemoglobin < 12 g/dL	0.56	0.37	0.75	1.78	1.34	2.35

ULN upper limit of normal 6/29/2021 10:54:00 AM

^aVariables highlighted in bold are part of the minimal predictor and SACOV-19

^bVariables highlighted in italic are part of the minimal predictor but not of SACOV-19