Abstract
Copper toxicosis of Bedlington Terriers (Chronic progressive hepatitis) is a genetically transmitted disease. The typical feature of this disease is accumulation of copper in the liver tissue. The changes vary from mild hepatitis to chronic progressive hepatitis and cirrhosis.
The material of this study consists of 2 cases of copper toxicosis examined at the Department of Pathology in Helsinki in the years 1980–82. Moreover a re-examination of tissue samples was made of all Bedlington Terriers examined during the years 1969–1982 at the same department. Six of the 14 examined dogs showed a positive reaction for copper in their liver tissues. The possible relationship of the examined dogs is not yet known.
Keywords: copper toxicosis, chronic progressive, hepatitis, Wilson’s disease
Sammandrag
Koppar toxikos är en ärftlig sjukdom hos Bedlington Terriers och typiskt för den är en accumulering av koppar i levern. Koppar lagras i hepatocy terna med leverskador varierande från lindriga degenerative ändringar till cirros soin följd. I detta arbete undersöktes njure, lever och hjärtmuskulatur av 14 hundar med en speciell koppar färg-ning. Sex av de 14 undersökta hundarna hade olika mängder av koppar i levern. Då sjukdomen är ärftlig, skall den beaktas i hundaveln även i Finland.
Full Text
The Full Text of this article is available as a PDF (768.7 KB).
References
- Golfischer S, Sternlieb J. Changes in the distribution of Hepatic Copper in relation to the progression of Wilson’s Disease (Hepatolenticular Degeneration) Amer. J. Pathol. 1968;53:883–901. [PMC free article] [PubMed] [Google Scholar]
- Hardy RM, Stevens JB, Stowe CM. Chronic progressive hepatitis in Bedlington Terriers associated with elevated copper concentrations. Minn. Vet. 1975;15:13–24. [Google Scholar]
- Johnson GF, Sternlieb J, Twedt DC, Grushoff DS, Schein-berg JH. Inheritance of copper toxicosis in Bedlington Terriers. Amer. J. vet. Res. 1980;41:1865–1866. [PubMed] [Google Scholar]
- Owen CA, Ludwig J. Inherited copper toxicosis in Bedlington Terriers. Amer. J. Pathol. 1982;106:432–433. [PMC free article] [PubMed] [Google Scholar]
- Twedt DC, Sternlieb J, Gilbertson SR. Clinical morphologic and chemical studies of copper toxicosis of Bedlington Terriers. J. Amer. vet. med. Ass. 1979;175:269–275. [PubMed] [Google Scholar]
- Uzman LL. Histochemical localization of copper with Rubeanic acid. Lab. Invest. 1956;5:299–305. [PubMed] [Google Scholar]