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. 1983 Dec 1;24(4):418–430. doi: 10.1186/BF03546715

Drug Withdrawal from Farmed Fish

Depletion of Oxytetracycyline, Sulfadiazine, and Trimethophrim from Muscular Tissue of Rainbow Trout (Salmo Gairdneri)

Tilbakeholdelse ved behandling au oppdrettsfisk. Utskilling au oxy-tetracyklin, sulfadiazin og trimethoprim fra muskelueu hos regnbue-ørret (Salmo gairdneri)

Ragnar Salte 1,✉, Knut Liestøl 1
PMCID: PMC8291279  PMID: 6675454

Abstract

A statistical approach to the setting of withdrawal times is presented. It is suggested that the time intercept between detection limit of the applied method of analysis, and the 90 % upper prediction limit of a linear regression on the logarithm of the tissue drug concentration provides a realistic estimate of the necessary withdrawal period at the temperatures considered. Recognizing that water temperature is an important determinant of pharcnaco-kinetics in fish, temperature-dependent withholding periods are recommended, i.e. 60 days at temperatures above 10°G and, for oxytetracycline, 100 days at temperatures between 7 and 10°G. The observed persistence of sulfadiazine and trimethoprim at lower water temperatures indicates that this drug mixture should be applied to slaughter fish only during summer.

Key words: medicated feed, Oxytetracycline, sulfadiazine, trimethoprim, elimination, residues, muscle, rainbow trout, Salmo gairdneri

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Footnotes

This study was financially supported by the Agricultural Research Council of Norway.

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