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. 1983 Dec 1;24(4):374–383. doi: 10.1186/BF03546711

Serum and Milk Concentrations of Several Sulphonamides and their N4-Acetyl Metabolites Following Oral Administration to Cows

Serum- och mjölkkoncentrationer av fiera sulfonamider samt deras N4-acetyl metaboliter efter oral giva át kor

Stefan Soback 1,✉, Ulla Lamminsivu 1, Pirta Tapio 1
PMCID: PMC8291282  PMID: 6675450

Abstract

Serum and milk concentrations of sulphonamides following oral administration of three commercial sulphonamide products to dairy cows were studied. The fate of the N4-acetyl derivatives of the compounds was also monitored. Sulfadimidine was found to have the slowest oral absorption rate compared to sulfametoxypyridazine, sulfa-phenazole and sulfanilamide. Sulfaphenazole was least absorbed. Excretion of the different sulfonamides into the milk was by passive diffusion and was best for the least ionized sulfanilamide followed by sulfadimidine and sulfamethoxypyridazine. The most ionized sulfaphenazole was not found in milk. Sulfanilamides was found to be readily acetylated (and sulfaphenazole to a lesser degree). N4-acetyl-sulfanilamide seemed to be actively secreted from blood into milk in the cow.

Key words: sulphonamides, farmaco kinetics, acetylation

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