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. 2020 Jun 17;11(1):661–678. doi: 10.1080/21655979.2020.1771068

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The higher expression paracrine factors from tumor-infiltrated dendritic cells. The dendritic cells were isolated from tumor or juxtatumor tissues, and RNA was extracted from dendritic cells and used to RNA-seq. (a) and (b). The enrichment of cytokines, chemokines, growth factors, and other paracrine factors from tumor-infiltrated CD1c⁻ (a) and CD1c⁺ dendritic cells. Enrichment index was calculated as the ratio of actually up-regulated genes to expectedly up-regulated genes. A.U. was arbitrary unit (c) and (d). The increased expression of cytokines and chemokines (c) as well as growth factors and other paracrine factors (d) in tumor-infiltrated CD1c⁻ dendritic cells compared with juxtatumor CD1c⁻ dendritic cells. (e, f) The increased expression of cytokines and chemokines (e) as well as growth factors and other paracrine factors (f) in tumor-infiltrated CD1c⁺ dendritic cells compared with juxtatumor CD1c⁺ dendritic cells.