Table 3.
Mixed model, repeated measures analysis of change from baseline using γ model
| Variable | Adjusted* least squares mean (95% CI) | Adjusted* mean difference (95% CI) | |||
|---|---|---|---|---|---|
| Intervention | Standard care | Intervention v standard care | P value | ||
| Total MSAS† | 0.36 (0.34 to 0.39) | 0.52 (0.49 to 0.54) | −0.15 (−0.19 to −0.12) | <0.001 | |
| MSAS global distress index | 0.46 (0.42 to 0.50) | 0.67 (0.63 to 0.71) | −0.21 (−0.27 to −0.16) | <0.001 | |
| MSAS psychological | 0.51 (0.46 to 0.55) | 0.67 (0.63 to 0.72) | −0.16 (−0.23 to −0.10) | <0.001 | |
| MSAS physical | 0.33 (0.30 to 0.36) | 0.54 (0.51 to 0.58) | −0.21 (−0.26 to −0.17) | <0.001 | |
| FACT-G total | 86.3 (85.3 to 87.3) | 82.3 (81.3 to 83.3) | 4.06 (2.65 to 5.46) | <0.001 | |
| FACT-G physical | 23.4 (21.3 to 23.7) | 21.6 (21.3 to 22.0) | 1.75 (1.25 to 2.25) | <0.001 | |
| FACT-G emotional | 20.4 (20.2 to 20.7) | 19.9 (19.6 to 20.1) | −0.54 (−1.23 to 0.16) | 0.13 | |
| FACT-G social | 23.6 (23.2 to 23.9) | 23.2 (22.8 to 23.5) | 0.44 (−0.06 to 0.93) | 0.08 | |
| FACT-G functional | 19.1 (18.7 to 19.5) | 17.5 (17.1 to 17.9) | 1.61 (1.00 to 2.22) | <0.001 | |
| STAI-R trait | 32.7 (32.2 to 33.3) | 33.9 (33.4 to 34.4) | −1.15 (−1.90 to −0.41) | 0.003 | |
| STAI-R state | 31.9 (31.2 to 32.6) | 33.0 (32.4 to 33.7) | −1.13 (−2.06 to −0.20) | 0.02 | |
| CASE-Cancer | 43.7 (43.3 to 44.2) | 42.9 (42.3 to 43.4) | 0.81 (0.19 to 1.43) | 0.01 | |
| SCNS-SF34 psychological | 23.2 (21.9 to 24.6) | 24.4 (23.0 to 25.8) | −1.14 (−3.04 to 0.75) | 0.24 | |
| SCNS-SF34 health system and information | 22.3 (21.1 to 23.4) | 23.7 (22.5 to 24.9) | −1.46 (−3.13 to 0.21) | 0.09 | |
| SCNS-SF34 sexuality needs | 12.0 (10.9 to13.1) | 13.5 (12.4 to 14.7) | −1.56 (−3.11 to −0.01) | <0.05 | |
| SCNS-SF34 patient care and support | 17.5 (16.5 to 18.6) | 19.3 (18.1 to 20.4) | −1.74 (−3.31 to −0.16) | 0.03 | |
| SCNS-SF34 physical and daily living | 27.3 (25.7 to 28.8) | 30.0 (28.5 to 31.6) | −2.8 (−5.0 to −0.6) | 0.01 | |
CASE-Cancer=Communication and Attitudinal Self-Efficacy scale for cancer; FACT-G=Functional Assessment of Cancer Therapy—General; MSAS=Memorial Symptom Assessment Scale; SCNS-SF34=Supportive Care Needs Survey Short-Form; STAI=State-Trait Anxiety Inventory.
*
Adjusted for baseline patient reported outcome measure, cycle, age, sex, cancer type, comorbidity, and country.
†
Primary outcome.