Figure 3. R.timonensis strains associated with the three beta-lactamase genes appear over the patient’s time course.

(a) Depiction of the reverse OIL-PCR in which Romboutsia-specific 16S rRNA sequences (blue) are fused with the bla_TEM sequences (red). (b) OIL-PCR read counts of the reaction shown in (a) are plotted. (c) The percent sequence identity of assembled R. timonensis marker genes between genes identified in timepoints 2 and 3 (top) and between timepoint 1 and between sequences shared at timepoints 2 and 3 (bottom). (d) RPKM-normalized abundance-values for the assembled marker genes for each strain assembled in time point one and the major strain present in timepoints 2 and 3.