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. 1981 Jun 1;22(2):189–197. doi: 10.1186/BF03547508

Effect of Prolactin Suppression on the Ovarian Activity in the Lactating Sow

Virkning av prolaktinsuppresjon på ovarialfunksjonen hos lakterende purker

Edvard Benjaminsen 1,✉
PMCID: PMC8300455  PMID: 7304360

Abstract

The effect of prolactin suppression during lactation was studied in 6 sows nursing 5–10 piglets. In order to inhibit prolactin secretion a dopamin agonist (bromocriptine, Parlodel® “Sandoz”) was given per os from about 4 weeks after parturition until weaning 9–17 days later. Plasma prolactin and plasma progesterone were determined by radioimmunoassays. In all animals plasma prolactin was suppressed during the bromocriptine treatment. Two sows resumed ovarian activity during treatment as indicated by elevated plasma progesterone, probably as a result of the low plasma prolactin levels. The results suggest that the elevated plasma prolactin levels during lactation is one of the factors responsible for lactational an oestrus in the sow.

Keywords: prolactin, bromocriptine, sow, lactation, lactational anoestrus

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Footnotes

Financial support was given by the Norwegian Agricultural Research Council.

References

  1. Ash R W, Heap R B. Oestrogen, progesterone and corticosteroid concentrations in peripheral plasma of sows during pregnancy, parturition, lactation and after weaning. J. Endocr. 1975;64:141–154. doi: 10.1677/joe.0.0640141. [DOI] [PubMed] [Google Scholar]
  2. Baird D T. Endocrinology of female infertility. Br. med. Bull. 1979;35:193–198. doi: 10.1093/oxfordjournals.bmb.a071569. [DOI] [PubMed] [Google Scholar]
  3. Baldwin D M, Stabenfeldt G H. Endocrine change in pig during late pregnancy, parturition and lactation. Biol. Reprod. 1975;12:508–515. doi: 10.1095/biolreprod12.4.508. [DOI] [PubMed] [Google Scholar]
  4. Benjaminsen E. Plasma prolactin in the sow with emphasis on variation in resumption of ovarian activity after weaning. Acta vet. scand. 1981;22:67–77. doi: 10.1186/BF03547208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Benjaminsen E, Karlberg K. Post weaning oestrus and luteal function in primiparous and pluriparous sows. Res. Vet. Sci. 1981;30:318–322. doi: 10.1016/S0034-5288(18)32550-5. [DOI] [PubMed] [Google Scholar]
  6. Bevers M M, Willemse A H, Kruip Th A M. Plasma prolactin levels in the sow during lactation and the postweaning period as measured by radioimmunoassay. Biol. Reprod. 1978;19:628–634. doi: 10.1095/biolreprod19.3.628. [DOI] [PubMed] [Google Scholar]
  7. Crighton D B, Lamming G E. The lactational anoestrus of the sow: The status of the anterior pituitary-ovarian system during lactation and after weaning. J. Endocr. 1969;43:507–519. doi: 10.1677/joe.0.0430507. [DOI] [PubMed] [Google Scholar]
  8. Edquist L E, Einarsson S, Settergren I. Ovarian activity and peripheral plasma levels of oestrogens and progesterone in the lactating sow. Theriogenology. 1974;1:43–49. doi: 10.1016/0093-691X(74)90005-3. [DOI] [PubMed] [Google Scholar]
  9. Elsaesser F, Parvizi N. Partial recovery of the stimulatory oestrogen feedback action on LH release during lactation in the pig. J. Reprod. Pert. 1980;59:63–67. doi: 10.1530/jrf.0.0590063. [DOI] [PubMed] [Google Scholar]
  10. Flückiger E. Effects of bromocriptine on the hypothalamio-pituitary axis. Acta Endocr. (Kbh.) 1978;88:111–117. [PubMed] [Google Scholar]
  11. Kann, G., J. Martinet & A. Schirar: Modifications of gonadotrophin secretion during natural and artificial hyperprolactinaemia in the ewe. In Crosignani, P. G. & C. Robyn, eds.: Prolactin and Human Reproduction. Academic Press, London 1977, pp. 47–59.
  12. van Landeghem A A J, van de Wiel D F M. Plasma prolactin levels in gilts during the oestrous cycle and at hourly intervals around the time of oestrus. Acta Endocr. (Kbh.) 1977;85:233. [Google Scholar]
  13. van Landeghem A A J, van de Wiel D F M. Radioimmunoassay for porcine prolactin: Plasma levels during lactation, suckling and weaning and after TRH administration. Acta Endocr. (Kbh.) 1978;88:653–667. doi: 10.1530/acta.0.0880653. [DOI] [PubMed] [Google Scholar]
  14. McNeilly A S. Effects of lactation on fertility. Br. med. Bull. 1979;35:151–154. doi: 10.1093/oxfordjournals.bmb.a071562. [DOI] [PubMed] [Google Scholar]
  15. McNeilly A S. Prolactin and the control of gonadotrophin secretion in the female. J. Reprod. Fert. 1980;58:537–549. doi: 10.1530/jrf.0.0580537. [DOI] [PubMed] [Google Scholar]
  16. Parvizi N, Elsaesser F, Smidt D, Ellendorff F. Plasma luteinizing hormone and progesterone in the adult female pig during the oestrous cycle, late pregnancy and lactation, and after ovariectomy and pentobarbitone treatment. J. Endocr. 1976;69:193–203. doi: 10.1677/joe.0.0690193. [DOI] [PubMed] [Google Scholar]
  17. Peters A R, Vyvoda S, Lamming G E. Comparison of plasma prolactin levels in the milked and suckling cow. J. Endocr. 1979;83:27–28. doi: 10.1677/joe.0.0830027. [DOI] [PubMed] [Google Scholar]
  18. Smith M S. The relative contribution of suckling and prolactin to the inhibition of gonadotrophin secretion during lactation in the rat. Biol. Reprod. 1978;19:77–83. doi: 10.1095/biolreprod19.1.77. [DOI] [PubMed] [Google Scholar]
  19. Veldhuis J D, Klase P, Hammond J M. Divergent effects of prolactin upon steroidogenesis by porcine granulosa cells in vitro: Influence of cytodifferentiation. Endocrinology. 1980;107:42–46. doi: 10.1210/endo-107-1-42. [DOI] [PubMed] [Google Scholar]
  20. Wiel, D. F. M. van de, A. A. J. van Landeghem, M. M. Bevers & A. H. Willemse: Endocrine control of pituitary and ovarian function during lactation in the sow. In Gaillard, P. J. and H. H. Boer, eds.: Comparative Endocrinology. Elsevier/North-Holland Biomedical Press, Amsterdam 1978, p. 378.
  21. Willemse, A. H., M. M. Bevers, D. F. M. van de Wiel, Th. A. M. Kruip & G. Eikelenboom: The effect of synthetic LH-RH on the LH release in the lactating sow. Proc. Int. Symp. on Central and Peripheral Regulation of Prolactin Function. Taormina 1979, pp. 63–64.
  22. Willemse, A. H., M. M. Bevers, Th. A. M. Kruip, D. F. M. van de Wiel & G. Eikelenboom: The role of prolactin in suppression of ovarian activity in the lactating sow. Proc. IPVS Congr., Copenhagen 1980, p. 23.

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