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. 2021 Jan 23;22(3-4):428–434. doi: 10.1186/BF03548668

Immunoglobulin Levels in Non-Aborted and Aborted Fetuses from Danish Herds of Cattle

Immunoglobulin niveau hos ikke-aborterede og aborterede fostre fra danske kvægbesætninger

H Bielefeldt Ohmann 1,✉
PMCID: PMC8300465  PMID: 7344532

Abstract

The applicability of serological tests in the diagnosis of intrauterine infections in Danish cattle was investigated. Fetuses from slaughter animals, experimentally infected and spontaneously aborted fetuses, premature and stillborn calves, were subjected to necropsy and histological studies, and to microbiological and serological examinations. The latter comprised rocket immunoelectrophoresis and radial immunodiffusion. In sera of the fetuses from slaughter animals, immunoglobulins were either not detectable or only present in very small quantities, whereas sera of fetuses and calves with pathological changes and/or verified infection contained considerable amounts of IgM and IgG. IgA was also detected in the latter group. The results corroborate the diagnostic importance of immunoglobulin determination in aborted fetuses and stillborn calves.

Keywords: bovine fetuses, intrauterine infection, immunoglobulins, cattle

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References

  1. Appleman R D, Owen F G. Breeding, housing and feeding management. J. Dairy Sci. 1975;58:447–464. doi: 10.3168/jds.S0022-0302(75)84588-7. [DOI] [Google Scholar]
  2. Bellamy J, Nielsen N O. Immune-mediated emigration of neutrophils into the lumen of the small intestine. Inf. Immun. 1974;9:615–619. doi: 10.1128/IAI.9.4.615-619.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bellamy J EC, Acres S D. Enterotoxigenic colibacillosis in colostrum-fed calves: Pathologic changes. Amer. J. vet. Res. 1979;40:1391–1397. [PubMed] [Google Scholar]
  4. Doughri A M, Altera K P, Storz J, Eugster A K. Ultrastructural changes in the chlamydia-infected ileal mucosa of newborn calves. Vet. Path. 1973;10:114–123. doi: 10.1177/030098587301000204. [DOI] [PubMed] [Google Scholar]
  5. Doughri A M, Young S, Storz J. Pathologic changes in intestinal chlamydial infection of newborn calves. Amer. J. vet. Res. 1974;35:939–944. [PubMed] [Google Scholar]
  6. Doughri A M, Storz J. Light and ultrastructural pathologic changes in intestinal Coronavirus infection of newborn calves. Zbl. Vet. Med. B. 1977;24:367–385. doi: 10.1111/j.1439-0450.1977.tb01011.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Husband, A. J., M. R. Brandon & A. K. Lascelles: Absorption and endogenous production of immunoglobulins in calves. In W. A. Hemmings: Antigen Absorption by the Gut. MTP Press Ltd., Lancaster 1978, p. 93–107.
  8. Keenan K P, Jervis H R, Marchwicki R H, Binn L N. Intestinal infection of neonatal dogs with canine Coronavirus 1–71: Studies by virologic, histologic, histochemical, and immunofluorescent techniques. Amer. J. vet. Res. 1976;37:247–256. [PubMed] [Google Scholar]
  9. Kent T H, Moon H W. The comparative pathogenesis of some enteric diseases. Based on cases presented at the 22nd annual seminar of the American College of Veterinary Pathologists. Vet. Path. 1973;10:414–469. [Google Scholar]
  10. Krunajevic, T.: Experimental virus enteritis in mink. A pathologicanatomical and electron microscopical study. Acta vet. scand. 1970, 11, Suppl. 30. [PubMed]
  11. Laksesvela B, Slagsvold P, Landsverk T. Indigestion in young calves. III. The influence of powders from heat-treated skim-milk and whey. Acta vet. scand. 1978;19:159–165. doi: 10.1186/BF03547621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Landsverk T. The gastrointestinal mucosa in young milk-fed calves. A scanning electron and light microscopic investigation. Acta vet. scand. 1979;20:572–582. doi: 10.1186/BF03546585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Landsverk, T.: The epithelium covering Peyer’s patches in young milk-fed calves. An ultrastructural and enzyme histochemical investigation. Acta vet. scand. 1981 a, 22, 198–210. [DOI] [PMC free article] [PubMed]
  14. Landsverk, T.: An enzyme histochemical investigation of the intestinal mucosa in diarrheic calves. Acta vet. scand. 1981 b, 22, 449–458. [DOI] [PMC free article] [PubMed]
  15. Landsverk, T.: Peyer’s patches and the follicle-associated epithelium in diarrheic calves. Pathomorphology, morphometry and acid phosphatase histochemistry. Acta vet. scand. 1981 c, 22, 459– 471. [DOI] [PMC free article] [PubMed]
  16. Landsverk, T. et al.: In prep.
  17. Mebus C A, Stair E L, Underdahl N R, Twiehaus M J. Pathology of neonatal calf diarrhea induced by a reo-like virus. Vet. Path. 1971;8:490–505. doi: 10.1177/0300985871008005-00612. [DOI] [Google Scholar]
  18. Mebus C A, Stair E L, Rhodes M B, Twiehaus M J. Pathology of neonatal calf diarrhea induced by a coronavirus-like agent. Vet. Path. 1973;10:45–64. doi: 10.1177/030098587301000105. [DOI] [PubMed] [Google Scholar]
  19. Morin M, Lamothe P, Gagnon A, Malo R. A case of viral neonatal calf diarrhea in a Quebec dairy herd. Canad. J. comp. Med. 1974;38:236–242. [PMC free article] [PubMed] [Google Scholar]
  20. Mowen, J. M. V. M.: White Scours in Piglets at Three Weeks of Age. Proefschrift, Rotterdam 1972.
  21. Padykula H A. Recent functional interpretations of intestinal morphology. Fed. Proc. 1962;21:873–879. [PubMed] [Google Scholar]
  22. Pearson G, Logan E F. The rate of development of post mortem artefact in the small intestine of neonatal calves. Brit. J. exp. Path. 1978;59:178–182. [PMC free article] [PubMed] [Google Scholar]
  23. Pearson G R, McNulty M S, Logan E F. Pathological changes in the small intestine of neonatal calves with enteric colibacillosis. Vet. Path. 1978;15:92–101. doi: 10.1177/030098587801500111. [DOI] [PubMed] [Google Scholar]
  24. Rijke R PC, Hanson W R, Plaisier H M, Osborne J W. The effect of ischemic villus cell damage on crypt cell proliferation in the small intestine. Evidence for a feedback control mechanism. Gastroenterology. 1976;71:786–792. [PubMed] [Google Scholar]
  25. Roy J HB. Problems in the nutrition of the preruminant calf. Proc. Nutr. Soc. 1974;33:79–86. doi: 10.1079/PNS19740017. [DOI] [PubMed] [Google Scholar]
  26. Specht, W.: Morphology of the intestinal wall. Its mucous membrane under normal and experimental conditions. In M. Kramer and F. Lauterbach: Intestinal Permeation. Proc. 4. Workshop Conf. Schloss Reisenburg, Excerpta Medica, Amsterdam 1977, p. 4–40.
  27. Stair E L, Mebus C A, Twiehaus M J, Underdahl N R. Neonatal calf diarrhea. Electron microscopy of intestine infected with a reovirus-like agent. Vet. Path. 1973;10:155–170. doi: 10.1177/030098587301000208. [DOI] [PubMed] [Google Scholar]
  28. Teir, H. & T. Rytomaa: Elimination of granulocytes in the intestinal tract and its pathological consequences. In E. Bajusz and G. Jasmin: Methods and Achievements in Experimental Pathology, vol. 1. S. Karger, Basel and New York 1966, p. 639–676.
  29. Todd W J, Doughri A M, Storz J. Ultrastructural changes in host cellular organelles in the course of the chlamydial developmental cycle. Zbl. Bakt. Hyg. I. Abt. Orig. A. 1976;236:359–373. [PubMed] [Google Scholar]

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