Abstract
Studies of transferrin (Tf) concentration in sera of sick horses were carried out using Mancini’s immunodiffusion technique. Relative values against a chosen reference serum were determined for a total of 112 horses.
Horses with acute infections had Tf values significantly below the normal. The lowest individual Tf value in this group (46%) was found in a six-months-old foal with temperature 41°C and watery diarrhoea.
Horses suffering from acute laminitis also had decreased Tf values. The lowest value in the whole material (45%) was found in a horse belonging to this group.
There was a positive correlation between the Tf value and the albumin content in serum.
Keywords: horse, serum transferrin concentration, diseases
Sammendrag
Det ble foretatt en undersökelse av transferrin (Tf) – konsentrasjonen i sera fra syke hester ved hjelp av Mancini’s immundiffusjonsteknikk. Relative verdier i forhold til et valgt referanseserum ble bestemt på et totalantall på 112 hester.
Hester med akutte infeksjoner hadde Tf-verdier som var signifikant lavere enn normale dyr. Den laveste individuelle verdi i denne gruppen (46%) ble funnet hos et 6 måneder gammelt föll med temperatur 41 °C og vanndig diaré.
Hester med akutt forfangenhet hadde også nedsatte Tf-verdier. Den laveste ver di i hele materialet (45%) ble funnet hos en hest som tilhörte denne gruppe.
Det var en positiv korrelasjon mellom Tf-verdien og albumininnholdet i serum.
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References
- Aisen Ph, Listowsky I. Iron transport and storage proteins. Ann. Rev. Biochem. 1980;49:357–393. doi: 10.1146/annurev.bi.49.070180.002041. [DOI] [PubMed] [Google Scholar]
- Ek N. Studies of electrophoresis on cellulose acetate membrane of serum proteins from normal horses, sheep and pigs. Acta vet. scand. 1970;11:295–304. doi: 10.1186/BF03547989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ek N. Concentration of serum prealbumin (Pr) protein in sick horses and its correlation to blood leucocyte count and albumin content in serum. Acta vet. scand. 1980;21:482–497. doi: 10.1186/BF03546836. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ek N. Antigen-antibody crossed electrophoretic studies and quantitative comparisons of serum transferrin types in horses. Acta vet. scand. 1981;22:246–259. doi: 10.1186/BF03547514. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Giblett, E. R.: Genetic Markers in Human Blood. Transferrin. Spottiswoode, Ballantyne and Co. Ltd., London and Colchester 1969.
- Kaneko, J. J. & C. E. Cornelius (eds.): Clinical Biochemistry of Domestic Animals. G. T. Dimopullos: Plasma Proteins. Acad. Press, New York and London 1970.
- Milano G, Cooper E H, Goligher J C, Giles G R, Munro Neville A. Serum prealbumin, retinol-binding protein, transferrin and albumin levels in patients with large bowel cancer. J. Natl. Cancer Inst. 1978;61:687–692. [PubMed] [Google Scholar]
- Snedecor, G. W. & W. G. Cochran: Statistical Methods. The Iowa State University Press, Ames, Iowa, USA 1967.
- Thoren-Tolling K. Serumproteinvariationer vid patologiska tillstånd hos häst och hund. (Serum protein variations with pathologic conditions in horses and dogs) Svensk Vet.-Tidn. 1977;29:917–927. [Google Scholar]
- Wiedermann D, Wiedermann B, Cidl K, Scudla V. Individual serum proteins and acute phase reactans in monoclonal immunoglobulinopathies : Patients with immunoglobulin A myeloma and light chain myeloma. Neoplasma (Bratisl.) 1979;26:315–324. [PubMed] [Google Scholar]
