Figure 4. The time course of mRNA and the effect of XNJI and muscone on the expression of mRNA of the ipsilateral cerebral cortex 168 h after TBI.

(A–D). The mRNA expression of bax, p53 and caspase-3 was significantly up-regulated 168 h after TBI while BCL-2 were down-regulated remarkably. The XNJI and muscone treatment down-regulated mRNA levels of bax, p53 and caspase 3 compared with the sham group, but BCL-2 had a reverse effect. N = 6, each group, ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^∗∗∗∗P < 0.0001.