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. 2021 Jan 23;22(3-4):493–500. doi: 10.1186/BF03548674

Growth of Some Lactic Acid Bacteria in Milk Containing Sulfadiazine

Växt av några mjölksyrabakterier i mjölk med Sulfadiatsinhalt

Stefan Soback 1,✉
PMCID: PMC8300503  PMID: 7344536

Abstract

A method for testing the effect of sulfonamides on lactic acid bacteria was developed. Sulfadiazine was used as the inhibitory substance. In the study 3 lactic acid bacteria, Lactobacillus lactis, Lactobacillus helveticus and Streptococcus thermophilus, were used. Lactic acid production, pH and plate count were used as parameters when monitoring the effect of Sulfadiazine on the test organisms under anaerobic conditions in milk medium.

A depressing effects due to Sulfadiazine on each of the test microbes could be demonstrated by all of the parameters used. Measurement of the inhibition in lactic acid production using Streptococcus thermophilus as test organism should be used when rapid determination of Sulfadiazine residues in milk is preferred.

Keywords: sulfadiazine, lactic acid bacteria, residues

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References

  1. Aldal, A. Personal communication 1964.
  2. Barnes J M, Magee P N. Some toxic properties of dimethylnitrosamine. Brit. J. industr. Med. 1954;11:167–174. doi: 10.1136/oem.11.3.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Druckrey H, Preussmann R, Ivankovic S, Schmähl D. Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. (Organotrophic carcinogenic effects of 65 different N-Nitrosocompounds in BD-rats). Z. Krebsforsch. 1967;69:103–201. [PubMed] [Google Scholar]
  4. Ender F, Havre G, Helgebostad A, Koppang N, Madsen R, Ceh L. Isolation and identification of a hepatotoxic factor in herring meal produced from sodium nitrite preserved herring. Naturwissenschaften. 1964;51:637–638. doi: 10.1007/BF00623677. [DOI] [Google Scholar]
  5. Freund H A. Clinical manifestations and studies in parenchymatous hepatitis. Ann. intern. Med. 1937;10:1144–1155. doi: 10.7326/0003-4819-10-8-1144. [DOI] [Google Scholar]
  6. Jacobson K H, Wheelwright H J, jr., Clem J H, Shannon R N. Studies on the toxicology of N-Nitrosodimethylamine vapor. Arch. industr. Hlth. 1955;12:617–622. [PubMed] [Google Scholar]
  7. Koppang, N.: Proceed. 9. Nordic Vet. Congr., Copenhagen 1962, pp. 777–778.
  8. Koppang N. An outbreak of toxic liver injury in ruminants. Nord. Vet.-Med. 1964;16:305–322. [Google Scholar]
  9. Koppang, N.: A severe progressive liver disease in fur animals. I. Symptoms and organ changes. Nord. Vet.-Med. 1966, 18, 205– 209.
  10. Koppang, N.: Dimethylnitrosamine — formation in fish meal and toxic effects in pigs. Amer. J. Path. 1974 a, 74, 95–106. [PMC free article] [PubMed]
  11. Koppang, N.: Toxic effect of dimethylnitrosamine in cows. J. nat. Cancer Inst. 1974 b, 52, 523–531. [DOI] [PubMed]
  12. Koppang, N.: The toxic effects of dimethylnitrosamine in sheep. Acta vet. scand. 1974 c, 15, 533–543. [DOI] [PMC free article] [PubMed]
  13. Koppang, N.: A survey of feeding N-Nitrosodimethylamine (NDMA) to domestic animals over an 18 year period. In: E. A. Walker, L. Griciute, M. Castegnaro & M. Börzsönyi (eds.). N-Nitroso Compounds: Analysis, Formation and Occurrence. IARC Scient. Publ. No. 31. Lyon 1980, pp. 779–785. [PubMed]
  14. Koppang N, Helgebostad A. Ondartet leversyke hos pelsdyr. (Malignant liver disease in fur animals). Norsk Pelsdyrblad. 1962;36:317–318. [Google Scholar]
  15. Koppang N, Helgebostad A. Toxic hepatosis in fur animals. II. The etiology eluciated by feeding experiments. III. Conditions affecting the formation of the toxic factor in herring meal. Nord. Vet.-Med. 1966;18:210–225. [Google Scholar]
  16. Koppang, N. & H. Rimeslåtten: Toxic and carcinogenic effects of nitrosodimethylamine in mink. In: E. A. Walker, P. Bogovski & L. Griciute (eds.) Environmental N-Nitroso Compounds Analysis and Formation. IARC Scient. Publ. No. 14, Lyon 1976, pp. 443–452. [PubMed]
  17. Lydersen, D. L. & K. Nagy: Polarographic determination of dimethylnitrosamine in fish products. Z. anal. Chem. 1967, 230, 277– 282.
  18. Magee P N, Barnes J M. The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine. Brit. J. Cancer. 1956;10:114–122. doi: 10.1038/bjc.1956.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Magee PN. Carcinogenic nitroso compounds. Adv. Cancer Res. 1967;10:163–246. doi: 10.1016/S0065-230X(08)60079-2. [DOI] [PubMed] [Google Scholar]
  20. McLean E, Bras G, McLean A E. Venous occlusions in the liver following dimethylnitrosamine. Brit. J. exp. Path. 1965;46:367–369. [PMC free article] [PubMed] [Google Scholar]
  21. O’Leary, J. F., A. H. Oikemus, B. Harrison & A. Brandsford: Some toxic effects of dimethylnitrosamine. Fed. Proc. 1955, 14, 375– 375.
  22. Sakshaug J, Søgnen E, Hansen M A, Koppang N. Dimethylnitrosamine, its hepatotoxic effect in sheep and its occurrence in toxic batches of herring meal. Nature (Lond.) 1965;206:1261–1262. doi: 10.1038/2061261b0. [DOI] [PubMed] [Google Scholar]

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