Table 4.

Studies associating telomere length and telomerase activity in granulosa cells/ovaries with POF.

Authors	Method	Population	Population Age (Years)	Results
Kinugawa et al., 2000 [98]	TRAP	(n = 5) POF (n = 20) Controls	31.4 <38	Ovarian TA: lower level in POF
Butts et al., 2009 [60]	PCR TRAP	(n = 12) POF (n = 42) Controls	30–37 23–37	GTL: shorter in POF GTA: absence of TA is more frequent in POF
Xu et al., 2017 [99]	PCR TRAP	(n = 120) POF (n = 90) Controls	32.95 ± 4.27 29.98 ± 4.28	GTL: shorter in POF GTA: lower level in POF

GTL, granulosa telomere length; GTA, granulosa telomerase activity; POF, premature ovarian failure; TRAP, telomere repeat amplification protocol; PCR, polymerase chain reaction.