Table 1.
Mechanosensitive TRPV channels in cancer progression.
| Possible Role in Cancer Progression | Channel | Mechanical Activation |
Mechanosensitive Pathways Involved |
Cell or Cancer Type | References |
|---|---|---|---|---|---|
| Migration | TRPV2 | Focal stimulation | Ca2+/PI3K/Akt/Rac1 | Fibroblasts | [259,284] |
| EMT | TRPV4 | Matrix stiffness | Ca2+/YAP/TAZ | NHEKs | [192] |
| EMT | TRPV4 | Matrix stiffness | Ca2+/YAP/TAZ/PI3K/Akt | NHEKs | [191] |
| EMT | TRPV6 | Stroma stiffness | Ca2+/CaMK | Breast epithelial cells | [45] |
| Angiogenesis | TRPV4 | Matrix stiffness | VE-cadherin | WT/TRPV4KO mice | [287] |
| Angiogenesis | TRPV4 | Matrix stiffness | Ca2+/Rho | CE cells | [57] |
| Angiogenesis | TRPV4 | Stretch | Ca2+/PI3K/β1 integrin | CE cells | [47,199] |