Table 1.
The main leptin modulators with anticancer activity.
| KERRYPNX | Designation | Cancer Type | In Vitro Studies | In Vivo Studies |
|---|---|---|---|---|
| Muteins | L39A/D40A/F41A (Lan-1) | Human Folliculoma | [110] | |
| L39A/D40A/F41A/I42A (Lan-2) | Ovarian Tumor | [109,111] | ||
| Human Folliculoma | [110,111] | |||
| D23L/L39A/D40A/F41A (SHLA) | Ovarian Tumor | [109,111] | ||
| Human Folliculoma | [110,111] | |||
| Peptides | LPrA-2 | Breast Cancer | [114] | [114] |
| Endometrial Cancer | [115] | |||
| IONP-LPAr2 | Breast Cancer | [114] | ||
| Pancreatic cancer | [117] | [117] | ||
| Allo-aca | Breast Cancer | [119,120,121] | [119,120,121] | |
| D-Ser | Breast Cancer | [122] | ||
| Colorectal Cancer | [122] | |||
| LDFI | Breast Cancer | [123,124] | [123] | |
| Seminoma | [95] | [95] | ||
| Glioblastoma | [127] | |||
| OB3 | Ovarian Cancer | [129] | [129] | |
| Hepatocellular Cancer | [131] | |||
| Antibodies | 9F8 | Breast Cancer | [135] | |
| Nanobodies | 2.17-mAlb | Melanoma | [142] | [142] |