Figure 2.

ERVK integrase and similar endogenous integrases share eukaryotic linear motifs patterns. Modified OneZoom image illustrating the conservation of ELM motifs in integrases from eukaryotic organisms (Homo sapiens, Macaca fasicicularis, Fukomys damarensis, Ochotona princeps, Equis asinus, and Capra hircus). Motifs are color-grouped according to function; DDR (blue), cell cycle (cyan), cell signaling (green), and intracellular trafficking (magenta). The number in each colored shape refers to the number of motifs with the respective integrase enzyme.