Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 5;10(7):1694. doi: 10.3390/cells10071694

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The levels of cellular senescence markers, such as Lamin B1, HMGB1 and SATB1, were significantly lower in human PD SNpc than age- and gender-matched control tissues, whereas the level of p21 was higher in human PD post-mortem SNpc (n = 8/group). In Western blots, the examples of senescence markers are displayed in quadruplets per group (A). The quantified levels of Lamin B1 (B), HMGB1 (C), SATB1 (D), p16 (E), p21 (F) and β-III-tubulin (G) were statistically analyzed in unpaired Student’s t-test for significance. The band intensity of GAPDH was normalized and displayed as relative band intensities (100% for age-matched controls, n = 8/group) in mean ± SEM. *: p < 0.05, **: p < 0.01, ***: p < 0.001 and ****: p < 0.0001. ns: not significant.