Figure 1.

Transcriptomic profile of Stim1^R304W/+ muscle. (A) RNAseq on Stim1^R304W/+ tibialis anterior samples revealed a comparable expression of the mutant and WT Stim1 alleles (n = 4). (B) Hierarchical clustering of the RNAseq data evidenced distinct sample grouping of WT and Stim1^R304W/+ mice (n = 4). (C) Classification of abnormally expressed genes in Stim1^R304W/+ tibialis anterior into gene ontology (GO) terms revealed an enrichment of groups associated with myofibril assembly and morphogenesis, Ca²⁺ transport and sarcoplasmic reticulum, and sarcomere organization and contraction. GO categories related to the immune system were removed from the analysis.