Table 2.
Pathway analysis using MetaboAnalyst and Reactome.
| Pathway Name | Pathway Source | Hits | Raw p | FDR |
|---|---|---|---|---|
| Alanine, aspartate, and glutamate metabolism | Metaboanalyst 4.0 | 8 | 4.09 × 10−18 | 1.60 × 10−16 |
| Purine metabolism | Metaboanalyst 4.0 | 2 | 1.42 × 10−12 | 2.04 × 10−11 |
| Glyoxylate and dicarboxylate metabolism | Metaboanalyst 4.0 | 8 | 1.76 × 10−12 | 2.04 × 10−11 |
| Aminoacyl-tRNA biosynthesis | Metaboanalyst 4.0 | 19 | 2.09 × 10−12 | 2.04 × 10−11 |
| Glycine, serine, and threonine metabolism | Metaboanalyst 4.0 | 7 | 1.20 × 10−8 | 9.36 × 10−8 |
| Glycolysis/gluconeogenesis | Metaboanalyst 4.0 | 3 | 8.12 × 10−8 | 3.52 × 10−7 |
| Arginine and proline metabolism | Metaboanalyst 4.0 | 6 | 6.76 × 10−7 | 2.46 × 10−6 |
| Arginine biosynthesis | Metaboanalyst 4.0 | 5 | 6.93 × 10−7 | 2.46 × 10−6 |
| Pyruvate metabolism | Metaboanalyst 4.0 | 3 | 3.45 × 10−6 | 1.12 × 10−5 |
| Cysteine and methionine metabolism | Metaboanalyst 4.0 | 3 | 4.70 × 10−6 | 1.41 × 10−5 |
| D-glutamine and D-glutamate metabolism | Metaboanalyst 4.0 | 2 | 2.63 × 10−5 | 6.84 × 10−5 |
| Nitrogen metabolism | Metaboanalyst 4.0 | 2 | 2.63 × 10−5 | 6.84 × 10−5 |
| Citrate cycle (TCA cycle) | Metaboanalyst 4.0 | 3 | 4.15 × 10−5 | 1.01 × 10−4 |
| Porphyrin and chlorophyll metabolism | Metaboanalyst 4.0 | 2 | 5.56 × 10−4 | 1.14 × 10−2 |
| Glutathione metabolism | Metaboanalyst 4.0 | 3 | 7.58 × 10−3 | 1.48 × 10−3 |
| Propanoate metabolism | Metaboanalyst 4.0 | 2 | 1.80 × 10−3 | 3.53 × 10−2 |
| Valine, leucine, and isoleucine biosynthesis | Metaboanalyst 4.0 | 4 | 2.36 × 10−1 | 4.19 × 10−1 |
| Tyrosine metabolism | Metaboanalyst 4.0 | 3 | 0.00010325 | 0.00017 |
| Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | Reactome | 2 | 0.005466565 | 0.37265 |
| Creatine metabolism | Reactome | 3 | 0.007243495 | 0.37265 |
| Proton-coupled monocarboxylate transport | Reactome | 2 | 0.007763673 | 0.37265 |
| Transport of bile salts and organic acids, metal ions, and amine compounds | Reactome | 5 | 0.037453248 | 0.50662 |
| Organic cation/anion/zwitterion transport | Reactome | 3 | 0.038381951 | 0.50662 |
| SLC-mediated transmembrane transport | Reactome | 8 | 0.042023926 | 0.50662 |
| Organic anion transporters | Reactome | 2 | 0.042882355 | 0.50662 |