Table 1.

Mitotherapy in animal models of disease by year of publication.

Study Reference	Experimental Model	Animal	Mito Source	Transplant	Route of Administration	Main Result
McCully et al., 2009 [7]	Heart regional ischemia	New Zealand White rabbits	Left ventricular tissue	Allogeneic	Injection into ischemic region	Enhancement of post-ischemic myocardial function
Masuzawa et al., 2013 [8]	Heart regional ischemia	New Zealand White rabbits	Pectoralis major muscle tissue	Autologous	Injection into ischemic region	Enhancement of post-ischemic myocardial function
Lin et al., 2013 [20]	Partial liver ischemia	Wistar rats	Liver	Allogeneic	Intrasplenic injection	Attenuation of hepatic injury
Cowan et al., 2016 [9]	Heart global ischemia	New Zealand White rabbits	Adult cardiac fibroblast culture	Autologous	Coronary artery injection	Enhancement of post-ischemic myocardial function
Su et al., 2016 [17]	Airway hyperresponsiveness	Sprague Dawley rats	Rat airway epithelial cells	Allogeneic	Intratracheally injection	Attenuation of airway remodeling and inflammatory response
Kaza et al., 2017 [10]	Heart regional ischemia	Yorkshire pigs	Pectoralis major muscle tissue	Autologous	Injection into ischemic region	Enhancement of myocardial cell viability
Fu et al., 2017 [15]	Non-alcoholic fatty liver disease	C57BL/6J mice	HepG2 cells	-	Intravenous injection (tail)	Attenuation of lipid accumulation and oxidative stress
Shi et al., 2018 [16]	Acetaminophen-induced liver injury	C57BL/6J mice	HepG2 cells	-	Intravenous injection (tail)	Attenuation of tissue injury and enhancement of hepatocyte metabolism
Moskowitzova et al., 2019 [11]	Heterotopic heart transplantation	C57BL/6J mice	Gastrocnemius muscle	Syngeneic	Coronary artery injection	Enhancement of graft function and attenuation of necrosis
Fu et al., 2019 [19]	Melanoma lung metastasis	BABL/c mice	Liver	Allogeneic	Intravenous injection (tail)	Retardation of tumor growth and prolonged animal survival
Moskowitzova et al., 2020 [18]	Acute lung ischemia-reperfusion	C57BL/6J mice	Gastrocnemius muscle	Syngeneic	Pulmonary artery injection and nebulization	Improvement of lung mechanics and attenuation of tissue injury
Guariento et al., 2020 [12]	Heart regional ischemia	Yorkshire pigs	Pectoralis major muscle tissue	Autologous	Preischemic coronary artery injection	Enhancement of post-ischemic myocardial function
Doulamis et al., 2020 [13]	Warm global ischemia	Zucker diabetic fatty rats	Pectoralis major muscle tissue or cardiac fibroblasts	Autologous and xenogeneic	Coronary artery injection	Enhancement of post-ischemic myocardial function