Table 2.

An overview of activated receptors in lung inflammation and their link to TRP channels.

Receptor	Function in Lung Inflammation	Involved TRP Channels
TLR4 (Toll-like receptor)	activation of NF-κB signaling pathway and thus initiation of cytokine production; DAG production [111]	DAG production activates TRPC1/4, TRPC3/6, and TRPC6 [1,81,84]
PAR1 (protease-activated receptor 1)	secretion of VEGF and formation of IP3 [91,114]	activation of TRPC1/4 and TRPC3/6 via IP3-dependent Ca2+ release from the endoplasmic reticulum [84,115]
VEGFR (vascular endothelial growth factor receptor)	DAG production [115]	DAG production activates TRPC1/4, TRPC3/6, and TRPC6 [84,104,123]