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. 2021 Jul 9;13(14):3440. doi: 10.3390/cancers13143440

Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624

Alessandro Liquori 1,, Mariam Ibañez 2,3,, Claudia Sargas 1, Miguel Ángel Sanz 2,3, Eva Barragán 2,3, José Cervera 2,3,*
PMCID: PMC8307399  PMID: 34298858

The authors wish to make the following corrections to this paper [1]:

In the last row of Table 2, translocation is t(3;17)(q26;q21) instead of t(1;17)(q42;q21).

Table 2.

APL molecular variants.

APL Molecular Variants Translocations ATRA Sensitivity ATO Sensitivity No. of Cases Reported Gene Other Than PML, Breakpoint Gene Other Than PML, Splice Site Genomic Insertions RARA, Breakpoint RARA, Splice Site Reference
ZBTB16 (PLZF)-RARA t(11;17)(q23;q21) Poorly responsive Poorly responsive >30 [85] Intron 3 CAGgtaggc Intron 2 ctctagCCA [102]
Intron 4 CTGgtgagt Intron 2 ctctagCCA [102]
NPM1-RARA t(5;17)(q35;q21) Sensitive ND 5 [103] Intron 5 CAGgtagag Intron 2 ctctagCCA [103]
Intron 5 CAGgtagag 79 nt with no homology to sequences in the GenBank or EMBL databases Intron 2 ctctagCCA [104]
Intron 4 TAGgtatgt Intron 2 ctctagCCA [103]
NUMA1 (NUMA)-RARA t(11;17)(q13;q21) Sensitive ND 1 Intron 23 CAGgtgagg Intron 2 ctctagCCA [89]
STAT5B-RARA der(17) Poorly responsive Poorly responsive 11 [105] Intron 15 CTCgtgagt Intron 2 ctctagCCA [90,105]
PRKAR1A-RARA t(17;17)(q21;q24) or del(17)(q21;q24) Sensitive Sensitive 1 Intron 2 AAGgtaaaa Intron 2 ctctagCCA [91]
FIP1L1-RARA t(4;17)(q12;q21) Sensitive in 1 case ND 2 Intron 15 ATGgtaagt Intron 2 ctctagCCA [92]
Intron 13 CGGgtaaat Intron 2 ctctagCCA [106]
BCOR-RARA t(X;17)(p11;q21) Sensitive in 2 cases Insensitive in 1 case 2 Intron 12 CAGgtatga Intron 2 ctctagCCA [93]
Exon 12 CAGgtagaa Intron 2 ctctagCCA [107]
NABP1 (OBFC2A)-RARA t(2;17)(q32;q21) Sensitive in vitro ND 1 Intron 5 TGGgtaaga Intron 2 ctctagCCA [94]
TBL1XR1 (TBLR1)-RARA t(3;17)(q26;q21) Insensitive ND 4 [108] Intron 5 CAAgtgagc Intron 2 ctctagCCA [95]
Intron 5 CAAgtgagc * Intron 2 ctctagCCA [108]
GTF2I-RARA t(7;17)(q11;q21) Sensitive Sensitive 1 Intron 6 TAGgtaagt Intron 2 ctctagCCA [96]
IRF2BP2-RARA t(1;17)(q42;q21) Sensitive Sensitive 5 [109] Exon 2 TGTcccctg Intron 2 ctctagCCA [97,109]
Exon 1 AAGgtgcgg Intron 2 ctctagCCA [110]
Intron 1 CAGgtaggg Intron 2 ctctagCCA [111]
Exon 1 CAGgcaggt Intron 2 ctctagCCA [111,112]
FNDC3B-RARA t(3;17)(q26;q21) Sensitive ND 1 Intron 24 AAGgtgtgt Intron 2 ctctagCCA [98]

The genes involved in APL molecular variants are reported according to the HUGO Gene Nomenclature Committee (https://www.genenames.org/, accessed on 8 March 2020). Previous symbols are reported in brackets. * According to molecular analysis, RARA on chromosome 17 had a 12-kbp deletion, of which a small region was inserted into chromosome X and the major part was inserted within the TBL1XR1 gene between exons 5 and 6 on chromosome 3 [108].

In the last row of Table 2, ATO sensitivity should be changed to ND (not determined) instead of “Sensitive”.

The new Table 2 is shown below:

The authors would like to apologize for any inconvenience caused to the readers by these changes. The original manuscript has been updated.

Funding

This research received no external funding.

Conflicts of Interest

The authors declare no conflict of interest.

Footnotes

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Reference

  • 1.Liquori A., Ibañez M., Sargas C., Sanz M.Á., Barragán E., Cervera J. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers. 2020;12:624. doi: 10.3390/cancers12030624. [DOI] [PMC free article] [PubMed] [Google Scholar]

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