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The mechanisms of RelB inhibition of p65/p50-mediated gene expression. (A) Dimer switching involves replacement of the p65/p50 complexes by the RelB/p50 complexes. (B) Epigenetic silencing involves recruitment of SIRT1, histone H3 deacetylation, and methylation. (C) Direct binding of p65 by RelB inhibits DNA binding. Histone H3, (H3); methyl, (Me); phosphate, (P); and Sirtuin 1, (SIRT1).
