Figure 15.

Cell localization post-mortem in ALS SOD1G93A mouse model without immunosuppression applied: Immunohistochemical staining in ALS SOD1G93A (allogenic) mice after 56 days of observation in the group with no immunosuppression applied. There were elevated MCP-1 levels (A) in the tissue, TMEM119 (B) and CD3+ (C,D), suggesting microglia activation. The GFP+ cells were very rare and the medium number of CD45+ cells with lymphocyte and macrophage morphology was present in the brain tissue (E,F). Abbreviations: ALS-amyotrophic lateral sclerosis; GFP-green fluorescent protein.