Table 2.
Measurement of skin hydration using Corneometer® CM825 and transepidermal water loss (TEWL) using Tewameter® TM300.
| Evaluation Parameter | Group | Measurement Sites | Week 0 | Week 4 | Week 8 | Week 12 |
|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | |||
| Corneometer | HA | Face | 49.5 ± 8.53 | 51.5 ± 6.55 | 52.8 ± 7.18 ** | 54.9 ± 7.06 ***† |
| (AU) 1 | Placebo | Face | 49.1 ± 8.13 | 49.4 ± 8.79 | 48.9 ± 9.36 | 48.8 ± 8.99 |
| HA | Arm | 33.9 ± 8.41 | 36.8 ± 6.90 | 36.1 ± 6.38 | 38.6 ± 7.99 ** | |
| Placebo | Arm | 35.4 ± 4.91 | 36.4 ± 5.78 | 35.1 ± 4.99 | 35.6 ± 4.38 | |
| HA | Waist | 29.7 ± 7.85 | 31.9 ± 7.60 | 30.4 ± 7.20 | 32.5 ± 7.14 * | |
| Placebo | Waist | 29.7 ± 5.26 | 31.0 ± 6.57 | 29.9 ± 6.38 | 30.2 ± 5.87 | |
| Tewameter | HA | Face | 12.8 ± 2.39 | 12.1 ± 1.85 | 12.0 ± 2.65 | 10.8 ± 2.49 ***†† |
| (g/h/m2) 2 | Placebo | Face | 12.6 ± 3.23 | 12.9 ± 2.67 | 13.0 ± 3.45 | 13.3 ± 3.09 |
| HA | Arm | 5.79 ± 1.86 | 5.45 ± 1.89 | 5.39 ± 2.10 | 5.40 ± 2.07 | |
| Placebo | Arm | 5.89 ± 2.43 | 5.94 ±3.06 | 5.31 ± 2.10 | 5.57 ± 1.90 | |
| HA | Waist | 3.47 ± 2.18 | 4.27 ± 1.53 | 3.60 ± 1.88 | 4.30 ± 1.88 | |
| Placebo | Waist | 3.74 ± 2.03 | 3.41 ± 1.32 | 3.72 ± 2.68 | 3.83 ± 1.91 |
1 AU, arbitrary units. 2 g/h/m2: water lost per hour per square meter of skin. * p-values (Dunnett’s test), compared with week 0; * indicates p < 0.05, ** indicates p < 0.01, and *** indicates p < 0.001; † p-values (t-test), comparisons between values in the HA and placebo groups; † indicates p < 0.05, and †† indicates p < 0.01. HA, hyaluronan; SD, standard deviation.