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. 2021 Jun 22;13(7):925. doi: 10.3390/pharmaceutics13070925

Figure 2.

Figure 2

Elevated STAT3 signaling in neutrophils and associated oxidative inflammation, and its inhibition by small-molecule pharmacological inhibitor Stattic in SJL/J mice with EAE: (A) % of p-STAT3+ GR-1+ cells. (B) An illustrative flow plot displaying immunostaining of p-STAT3+ and GR-1+ cells. (C) % of IL-1β+ GR-1+ cells. (D) An illustrative flow plot displaying immunostaining of IL-1β+ and GR-1+ cells. (E) % of iNOS+ GR-1+. (F) An illustrative flow plot displaying immunostaining of iNOS+ and GR-1+ cells. (G) % of Nitrotyrosine+ GR-1+. (H) An illustrative flow plot displaying immunostaining of Nitrotyrosine+ and GR-1+ cells. Data are expressed as mean ± SEM, n = 6/group. * p < 0.05 vs. Veh + Control SJL/J group/ Stattic + Control SJL/J group; # p < 0.05 vs. Veh + EAE SJL/J group.