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. 2021 Jun 22;13(7):925. doi: 10.3390/pharmaceutics13070925

Figure 3.

Figure 3

Elevated STAT3 signaling in CD4+ T cells and associated inflammation, and its inhibition by small-molecule pharmacological inhibitor Stattic in SJL/J mice with EAE: (A) % of p-STAT3+ CD4+ T cells. (B) An illustrative flow plot displaying immunostaining of p-STAT3+ and CD4+ T cells. (C) % of IL-17A+ CD4+ T cells. (D) An illustrative flow plot displaying immunostaining of IL-17A+ and CD4+ T cells. (E) % of IL-23R+ CD4+ T cells. (F) An illustrative flow plot displaying immunostaining of IL-23R+ and CD4+ T cells. Data are expressed as mean ± SEM, n = 6/group. * p < 0.05 vs. Veh + Control SJL/J group/Stattic + Control SJL/J group; # p < 0.05 vs. Veh + EAE SJL/J group.