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Elevated STAT3 signaling in the CNS and associated inflammation, and its inhibition by small-molecule pharmacological inhibitor Stattic in SJL/J mice with EAE: (A) p-STAT3 protein levels; (B) IL-17A mRNA expression; (C) IL-17A protein levels; (D) IL-1β mRNA expression; (E) IL-1β protein levels. Data are expressed as mean ± SEM, n = 6–8/group. * p < 0.05 vs. Veh + Control SJL/J group/ Stattic + Control SJL/J group; # p < 0.05 vs. Veh + EAE SJL/J group.
