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Molecular dynamics simulations demonstrate Cys311 restrains a CTD motif, whereas C311A enhances the CTD motif flexibility and C311A membrane binding. (A) Cys311 interacting with the two polar residues (Ser199, Asn200) in the GSNG motif. (B) C311A mutation enhances the flexibility of the GSNG motif, which underlies the CTD lipid binding surface of VP40. (C) Distance between the Cα atoms of residues 201 and 311 (purple: WT, green: C311A).
