Figure 3.

Overproduced ROS elimination accompanied by ROS-induced polymeric degradation. (A) Effects of RAPA@BMHOP on H₂O₂-induced HUVECs and untreated HUVECs (values represent mean ± SD, n = 6, **P < 0.01, ns, no significance). (B) CLSM images from three different RAPA@NPs on intracellular ROS elimination at different time points (scale bar = 5 μm). (C) CLSM images of red fluorescent signals of DHE for detecting ROS levels in the ischemic brain (scale bar = 20 μm). (D) Schematics of controlled drug release from ROS facilitating breakage of active chemical bonds.