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Identification of CD4-restricted T-cell epitopes
(A) IFN-γ production by T-cells in response to PRAME peptide pool stimulation. (B)(C) T-cell responses to single PRAME peptides, present in the mini-pools 2, 11, 17, and 18, were evaluated by IFN-γ ELISpot assay. (D) HLA-II-restricted epitopes (50 and 71) were determined by measuring IFN-γ and TNF-α release by CD4+ T-cells. (E) CD8+ T-cells did not release IFN-γ and TNF-α in response to class II-restricted epitopes.
