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. 1980 Mar 1;21(1):18–25. doi: 10.1186/BF03546896

Plasma and Tissue Levels of Trimethoprim in The Rainbow Trout, Salmo Gairdneri, After Absorption From Fresh and Salt Water

Plasma- og vevskonsentrasjoner av trimethoprim hos regnbueørret, Salmo gairdneri, etter absorpsjon fra ferskvann og saltvann.

Torill Bergsjø 1,✉, Erling Søgnen 1
PMCID: PMC8317695  PMID: 7386327

Abstract

This is a comparative study of uptake of trimethoprim from 1) fresh water, 2) salt water after 7 days of adaption and 3) salt water without previous adaptation. The rate and extent of absorption were found to vary significantly. The salt water adapted group reached a plasma concentration of approx. 1 µg/ml after 10 h, the unadapted salt water group after 24 to 48 h and the fresh water group did not reach this concentration. The results are discussed in relation to the non-ionic diffusion theory and to the alterations taking place in euryhaline species of fish during adaptation to salt water.

Keywords: trimethoprim, rainbow trout, Salmo gairdneri, absorption, fresh water, salt water

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