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. 1980 Jun 1;21(2):197–208. doi: 10.1186/BF03546883

Anemia and Growth Retardation in Totally Gastrectomized Swine

Anæmi og hæmmet tilvækst hos totalt gastrektomerede svin.

Svend Petri 1,✉, Folke Rasmussen 1, Claus Petri 1
PMCID: PMC8317706  PMID: 7395681

Abstract

The effects of total gastrectomy in six young swine were followed and described during an experimental period up to 18 months. Two of the gastrectomized pigs (Nos. 1 and 2) were medicated with cycobemin every second week. Two other gastrectomized pigs (Nos. 11 and 14) were medicated with iron-dextran twice a week. Three non-gastrectomized swine receiving the same feed as the gastrectomized animals were observed as controls for up to eight months.

One of the gastrectomized non-medicated pigs (No. 4) did not gain weight, while the other gastrectomized animals had a normal appearance and gained weight but less than the controls. The non-medicated as well as the cycobemin-medicated gastrectomized animals developed a microcytic hypochrome anemia corresponding to the anemia in iron deficiency. Histochemically loss of iron in the depots (liver, spleen, bone marrow and intestine) was demonstrated in the gastrectomized animals except those treated with iron-dextran. Histological and histochemical examinations of the nervous system did not show any abnormalities.

Keywords: gastrectomy, swine, anemia

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Footnotes

Financially aided by a grant from the P. Carl Petersen Foundation.

References

  1. Adams, C. W. M.: A histochemical method for the simultaneous demonstration of normal and degenerating myelin. J. Path. Bact. 1959, 77, 648–651. [DOI] [PubMed]
  2. Bodian C. A new method for staining nerve fibers and nerve endings in mounted paraffin sections. Anat. Rec. 1936;65:89–97. doi: 10.1002/ar.1090650110. [DOI] [Google Scholar]
  3. Bunting, H.: The histochemical detection of iron in tissues. Stain Technol. 1949, 24, 109-415. [DOI] [PubMed]
  4. Cunha, T. J.: Swine Feeding and Nutrition. Interscience Publishers, Inc., New York 1957.
  5. Cunningham H. M. Digestibility, rate of passage and rate of gain in the gastrectomized pig. J. Animal Sci. 1967;26:500–503. doi: 10.2527/jas1967.263500x. [DOI] [PubMed] [Google Scholar]
  6. Einarson L. A method of progressive selective staining of Nissl and nuclear substance in nerve cells. Amer. J. Path. 1951;8:295–308. [PMC free article] [PubMed] [Google Scholar]
  7. Harper, H. A.: Review of Physiological Chemistry. 8th Ed. Lange Medical Publications, Los Altos, California 1961, 320–323.
  8. Hedrich M. F., Elliot J. M., Lowe J. E. Response in vitamin B-12 production and absorption to increasing cobalt intake in the sheep. J. Nutr. 1973;103:1646–1651. doi: 10.1093/jn/103.12.1646. [DOI] [PubMed] [Google Scholar]
  9. Hoff-Jørgensen E. Microbiological assay of vitamin B12. Meth. biochem. Anal. 1954;1:81–113. doi: 10.1002/9780470110171.ch4. [DOI] [PubMed] [Google Scholar]
  10. Kristensen, H. P. Qstergaard: Vitamin B12-indholdet i Menneskeblod. (The contents of vitamin B12 in human blood). Thesis. Copenhagen 1958.
  11. Lillie R. D., Ashburn L. L. Supersatured solutions of fat stains in dilute isopropanol for demonstrations of acute fatty degeneration not shown by Herxheimer technique. Arch. Path. 1943;36:432–435. [Google Scholar]
  12. Lison L. Sur de nouveaux colorant histologiques spécifiques des lipides. (New histological stainings specific for lipids) G. R. Soc. Biol. (Paris) 1934;115:202–205. [Google Scholar]
  13. Maison, G. L. & A. C. Ivy: Gastrectomy and subsequent hematologic studies in the dog. Proc. Soc. exp. Biol. (N.Y.) 1933/34, 31, 554–556.
  14. McManus J. F. A. Histological demonstration of mucin after periodic acid. Nature (Lond.) 1946;158:202. doi: 10.1038/158202a0. [DOI] [PubMed] [Google Scholar]
  15. McManus J. F. A. Histological and histochemical uses of periodic acid. Stain Technol. 1948;23:99–108. doi: 10.3109/10520294809106232. [DOI] [PubMed] [Google Scholar]
  16. Nørgaard, Fl.: Histological changes in the central nervous system in experimental endogenous gastroprival pellagra in swine and dog. Thesis. E. Munksgaard, Copenhagen 1942.
  17. Perls M. Nachweis von Eisenoxyd in gewissen Pigmenten. (Demonstration of oxidized iron in certain pigments) Virchows Arch. path. Anat. 1867;29:42–48. doi: 10.1007/BF01878983. [DOI] [Google Scholar]
  18. Petri, S.: Bibliography of the papers by Svend Petri up to 1955, appears in Dissertationes in honorem Svenonis Petri sexagenarii. Acta path, microbiol. scand. 1955, Suppl. 105, 12–15. [PubMed]
  19. Petri S., Bøggild D., Søeborg Ohlsen A., Wanscher O. Experimentelle Untersuchungen über gastrogene Anämien und damit einhergehenden Avitaminose Veränderungen. VII. Über die bei Schweinen nach Ventrikelextirpation beobachteten Veränderungen. (Experiments on gastroprive anemia and avitaminoses. VII. Changes in relation to gastrectomy in swine). Acta path, microbiol. scand. 1937;14:111–120. [Google Scholar]
  20. Petri S., Nørgaard FL, Bandier E. Studies on the causation of experimental gastroprival pellagra. Acta med. scand. 1940;103:584–606. doi: 10.1111/j.0954-6820.1940.tb09057.x. [DOI] [Google Scholar]
  21. Petri, C., Folke Easmussen & S. Petri: Anaemia in the totally gastrectomized pig. In Advance Abstracts, 4th World Congr. Gastroenterology, Danish Gastroent. Ass., Copenhagen 1970, 574.
  22. Petri S., Petri C., Rasmussen Folke. Vitamin B12 in the blood and in the liver of normal and of totally gastrectomized pigs. Acta vet. scand. 1973;14:421–427. doi: 10.1186/BF03547429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tseng R. Y. L., Cohen N. L., Reyes P. S., Briggs G. M. Metabolic changes in golden hamsters fed vitamin B12-deficient diets. J. Nutr. 1976;106:77–85. doi: 10.1093/jn/106.1.77. [DOI] [PubMed] [Google Scholar]
  24. Weil, A.: Textbook on Neuropathology. Lea and Febiger, Philadelphia, 1933.

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