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Antitumor activity of dostarlimab monotherapy in a humanized mouse model of breast cancer. (a) Study schema; dostarlimab or IgG4 isotype control (200 μg/mouse, twice weekly) was dosed to already established MDA-MB-436 tumors (80–120 mm3) grown as xenografts in humanized NOG-EXL mice (Taconic), and (b) antitumor activity. PD-1: programmed cell death protein 1; IgG: immunoglobulin G
