Table 1.
Biochemical and cell-based binding of dostarlimab to PD-1
| Kinetic parameters (SPR) |
PD-1–expressing CHO cellsa | |||
|---|---|---|---|---|
| Kassoc (M–1s–1) | Kdissoc (s–1) | KD (nM) | EC50 (nM) | |
| Human PD-1 | 5.7 × 105 | 1.7 × 10–4 | 0.30 | 2.0 |
| Cynomolgus PD-1 | 4.3 × 105 | 2.3 × 10–4 | 0.53 | 3.4 |
aDostarlimab binding was not detected on nontransfected CHO cells.
CHO: Chinese hamster ovary; EC50: half-maximal effective concentration; Kassoc: association rate constant; KD: dissociation constant; Kdissoc: dissociation rate constant; SPR: surface plasmon resonance.