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. 2021 Mar 24;144(6):1661–1669. doi: 10.1093/brain/awab076

Figure 3.

Figure 3

CSPα restores dopamine release impairment in 1-120hαSyn mice. Striatal DA release after infusion of 50mM KCl for 60 min during in vivo microdialysis. Twelve-month-old 1-120hαSyn mice showed a significant reduction in DA release following KCl stimulation compared with controls (***P < 0.001, *P < 0.05). Values are expressed as fold change normalized to peak control mice value. Increase of CSPα following AAVCSPα injection restored DA release to control levels in 1-120hαSyn mice whereas treatment with AAVEV was ineffective (fractions: 60 min ##P < 0.01, 80 min #P < 0.05). No significant difference was observed in the 60 and 80 min fractions between CSPα and EV-treated or untreated control mice. Values are mean ± SEM of n = 5–7 1-120hαSyn and n = 5–6 control mice per treatment group, two-way ANOVA, Bonferroni’s multiple comparison test.