Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang; Linqi Zhang

doi:10.1007/s11684-019-0721-9

. 2019 Dec 19;14(1):30–42. doi: 10.1007/s11684-019-0721-9

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang ¹, Linqi Zhang ^1,^✉

PMCID: PMC8320319 PMID: 31858368

Abstract

Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiency virus type I (HIV-1) through antiretroviral therapy. However, vaccine development has remained challenging. Recent discoveries in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccine approaches for inducing bNAbs-like antibody response. Structural and dynamic studies revealed several vulnerable sites and states of the HIV-1 envelop glycoprotein (Env) during infection. Our review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and development.

Keywords: HIV-1, broadly neutralizing antibodies, Env conformational states, vaccine design, SOSIP

Compliance with ethics guidelines

Qian Wang and Linqi Zhang declare that they have no conflict of interest. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang

Linqi Zhang

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang

Linqi Zhang

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