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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Stroke. 2021 May 5;52(6):2162–2173. doi: 10.1161/STROKEAHA.120.032736

Fig. 6. HMBG1 interaction with TREM-1 modulated microglia polarization after ICH.

Fig. 6

(A) Representative immunoblots and quantitative analysis of HMGB1 expression after ICH. The error bars represent mean±SD. *P<0.05 vs sham. N=6 per group. (B) Co-IP showed TREM-1 binding to endogenous HMBG1 was detected after ICH. (C) HMGB1 selective inhibitor, Glycyrrhizin promoted M2 microglia polarization at 24h after ICH and TREM-1 activator, anti-TREM-1 mAb reversed this effect. The error bars represent mean±SD. *P<0.05 vs sham, #P<0.05 vs ICH, $P<0.05 vs Glycyrrhizin. N=4 per group.