Table 1. Enriched Biological Process Gene ontology (GO) terms in the 102 differentially expressed genes (DEGs) in CB002-analog #4 treated cells.
GO analysis for the 102 DEGs that are also known p53 target genes. GO term analysis was done using the R package ‘goseq’ and those genes enriched in particular biological process are described along with their adjp value. Top 25 enriched GO terms are listed.
| GO term ID | Name | Adjp |
|---|---|---|
| GO:0008219 | Cell death | 4.447579E−08 |
| GO:0010941 | Regulation of cell death | 4.447579E−08 |
| GO:0012501 | Programmed cell death | 5.409503E−08 |
| GO:0006915 | Apoptotic process | 5.466988E−08 |
| GO:0043067 | Regulation of programmed cell death | 2.902278E−07 |
| GO:0097193 | Intrinsic apoptotic signaling pathway | 4.205507E−07 |
| GO:0097190 | Apoptotic signaling pathway | 4.949351E−07 |
| GO:0042981 | Regulation of apoptotic process | 6.67383E−07 |
| GO:0072331 | Signal transduction by p53 class mediator | 7.248333E−07 |
| GO:0050896 | Response to stimulus | 7.321667E−07 |
| GO:0007154 | Cell communication | 1.104964E−06 |
| GO:0051716 | Cellular response to stimulus | 1.532609E−06 |
| GO:0023052 | Signaling | 2.587082E−06 |
| GO:0007165 | Signal transduction | 2.587082E−06 |
| GO:0009966 | Regulation of signal transduction | 5.993752E−06 |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class | 1.671799E−05 |
| GO:0048583 | Regulation of response to stimulus | 3.853858E−05 |
| GO:2001233 | Regulation of apoptotic signaling pathway | 3.893307E−05 |
| GO:0010646 | Regulation of cell communication | 4.168569E−05 |
| GO:0007166 | Cell surface receptor signaling pathway | 4.430113E−05 |
| GO:0023051 | Regulation of signaling | 5.136280E−05 |
| GO:0010942 | Positive regulation of cell death | 8.303541E−05 |
| GO:0043065 | Positive regulation of apoptotic process | 1.220935E−04 |
| GO:0048584 | Positive regulation of response to stimulus | 1.220935E−04 |
| GO:0009968 | Negative regulation of signal transduction | 1.220935E−04 |