Table 2. Contribution of transcription factors P53, ATF4, and E2F to differentially expressed genes (DEGs) in CB002-analog #4 treated cells.

The total number of DEGs that overlapped with known genes of each transcription factor was calculated. This total is reflected in the ‘number of genes in DEG’ column. Using this number, we then calculated the ratio of DEGs divided by the total of genes in the transcription factor data set.

Transcription factor	Number of genes in DEG	Number in data set	Ratio
P53	73+10+2+17=102	343	0.3
ATF4	127+10+19+2=158	559	0.28
E2F	17+2+19+210=248	1444	0.17