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. 1979 Mar 1;20(1):25–37. doi: 10.1186/BF03546626

The Distribution of 35S-Sulfadiazine and 14G-Trimethoprim in Rainbow Trout, Salmo Gairdneri

Fordelingen av 35S-sulfadiazin og 14C-trimethoprim hos regnbueørret, Salmo gairdneri

Torill Bergsjø 1, Inger Nafstad 1, Kristian Ingebrigtsen 1,✉
PMCID: PMC8322892  PMID: 443139

Abstract

The distribution of 35S-labelled sulfadiazine and 14G-labelled trimethoprim was studied in rainbow trout by use of whole body autoradiography and liquid scintillation. As compared to mammals, gastrointestinal absorption and elimination were slow. Accumulation in the skin and the uveal tract of the eye was observed for both drugs tested. The results also indicated that the bile was an important route of excretion. Considerable radioactivity was still present in the skin at 144 hr. survival time.

Keywords: 35S-sulfadiazine, 14C-trimethoprim, rainbow trout, Salmo gairdneri, whole body autoradiography

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